The effects of antioxidant dietary supplements on oxidative stress and its implications in Metabolic Syndrome: a review


  • Giuseppe Potrick Stefani Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)
  • Bruna Marmett Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)
  • Cláudia Ramos Rhoden Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)


Metabolic Syndrome X, Dietary supplements, Antioxidant, Oxidative stress


The aim was to perform a review in order to elucidate the actions and efficacy of different antioxidant supplements used on Metabolic Syndrome. The articles were searched during October of 2015 to December of 2018, using the databases PubMed and Web of Knowledge. The keywords used were: “Metabolic Syndrome” AND “dietary supplements” OR “antioxidant”. The included articles were published from 2010 and in English. It was applied for articles selection inclusion and exclusion criteria. The articles that fulfilled criteria were analyzed through a full-text reading. Search results in 368 articles (PubMed: 198; Web of Knowledge: 170). After eliminating duplicated data and applying criteria, 16 articles were included to the review. The antioxidant supplements used on the studies included eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), nigella sativa (NS) and garlic, superoxide dismutase (SOD), cholecalciferol, Coenzyme Q10 (CoQ10), quercetin dehydrate, glycine, α-lipoic acid (ALA), glutathione precursor (F1), taurine, phenolic acids, red yeast rice-olive extract, curcumin, goji berry and arginine. Findings demonstrate a decrease in oxidative stress by increasing antioxidant enzyme activity, G6DH, Nrf2 with a consequently positive effect on insulin sensitivity, glucose tolerance, improvement in lipid profile, decrease on inflammatory and endothelium dysfunction markers with antioxidant supplements. Therefore, we could conclude that supplementation with antioxidant potential is able to ameliorate parameters of Metabolic Syndrome.


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Biografia do Autor

Giuseppe Potrick Stefani, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)

Possui Graduação em Nutrição pela Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Mestrado em Ciências da Saúde com ênfase em Fisiologia e Fisiopatogênese (UFCSPA) e Especialização em Nutrição Clínica e Esportiva pelo Instituto de Pesquisas e Gestão em Saúde (iPGS). Atualmente é docente dos cursos de Pós-Graduação em Nutrição Esportiva e Treinamento Físico pela UNISINOS, Pós-Graduação em Nutrição Clínica e Esportiva pelo iPGS. Tem experiência na área de Nutrição Esportiva com ênfase em Fisiologia do Exercício, Fisiologia Cardiovascular atuando principalmente nos seguintes temas: suplementação, treinamento de força, estresse oxidativo e insuficiência cardíaca. Possui qualificação internacional concedida pela Sociedade Internacional para Avanço da Cineantropometria (ISAK), sendo cineantropometrista nível II.

Bruna Marmett, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)

Possui Graduação em Nutrição pela Universidade Federal de Ciências da Saúde de Porto Alegre (2014) e Mestrado em Ciências da Saúde (UFCSPA) (2017). Atualmente é aluna de Doutorado em Ciências da Saúde (UFCSPA), atuando em pesquisas no Laboratório de Poluição Atmosférica nas áreas de poluição atmosférica, monitoramento ambiental, exercício físico, suplementação, estresse oxidativo e dano em DNA.

Cláudia Ramos Rhoden, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA)

possui graduação em Farmácia pela Universidade Federal do Rio Grande do Sul (1986), especialização em Análises Clínicas pela Universidade Federal do Rio Grande do Sul (1987), mestrado em Farmacologia pela Fundação Faculdade Federal de Ciências Médicas de Porto Alegre (1991), doutorado em Ciências Biológicas (Fisiologia) pela Universidade Federal do Rio Grande do Sul (2000) e pós-doutorado no Programa de Fisiologia com ênfase em Ciência Ambiental na Harvard University (2002). Atualmente é professora da Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), criada em janeiro de 2008 a partir da transformação da Fundação Faculdade Federal de Ciências Médicas de Porto Alegre; e coordenadora do Laboratório de Poluição Atmosférica na UFCSPA. Também é Pesquisadora Associada junto ao Departamento de Patologia da Faculdade de Medicina da Universidade de São Paulo.


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Como Citar

Stefani, G. P., Marmett, B., & Rhoden, C. R. (2019). The effects of antioxidant dietary supplements on oxidative stress and its implications in Metabolic Syndrome: a review. Revista Da Associação Brasileira De Nutrição - RASBRAN, 10(1), 117–127. Recuperado de



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