Microbiota intestinal e síndrome metabólica: utilização terapêutica de probióticos
DOI:
https://doi.org/10.47320/rasbran.2022.1451Keywords:
Microbioma Gastrointestinal. Síndrome metabólica. Probióticos.Gastrointestinal Microbiome. Metabolic Syndrome. ProbioticsAbstract
Objetivo: Explorar as alterações encontradas na microbiota intestinal na presença de parâmetros da síndrome metabólica e os efeitos da suplementação de probióticos como medida terapêutica. Metodologia: Consiste em um estudo de revisão, realizado pela busca de artigos científicos nas bases de dados Medline e Scielo utilizando os descritores Microbioma Gastrointestinal, Síndrome Metabólica e Probióticos, publicados nos idiomas português, inglês e espanhol. Resultados: Constatou-se que a síndrome metabólica cursa com a disbiose do microbioma intestinal com aumento da proporção de alguns filos e gêneros bacterianos em detrimento de outros. Como resultado, há maior estímulo para o ganho de peso corporal, resistência à insulina, diabetes mellitus do tipo 2, dislipidemia e hipertensão arterial. A suplementação de probióticos esteve relacionada à efeitos positivos quanto à redução do peso corporal, glicemia de jejum, níveis pressóricos e alterações benéficas das subfrações do perfil lipídico. Entretanto, existem divergências nos achados quanto ao real papel da microbiota sobre o desenvolvimento da síndrome metabólica e os efeitos dos probióticos, enquanto agente de tratamento. Conclusão: A microbiota intestinal encontra-se alterada durante a síndrome metabólica, porém, mais estudos são necessários para comprovar a associação causal entre a disbiose e a gênese de parâmetros da síndrome metabólica, assim como mais experimentos randomizados são precisos para evidenciar os probióticos como medida terapêutica para a síndrome metabólica.
Palavras-chave: Microbioma Gastrointestinal. Síndrome Metabólica. Probióticos
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